© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)

Tijdens zijn bewogen leven schreef Dirck Volckertsz Coornhert (1522-1590) vele teksten en voerde hij talloze gesprekken. Zijn doel: zijn medemensen overtuigen van het belang om niet slaafs achter anderen aan te lopen maar zélf na te denken. Want elk mens heeft voldoende redelijke vermogens om het leven zelfstandig vorm te geven en het goede te doen. De Kruidhofjes bevat twee bundels met dialogen – gesprekken die Coornhert zelf voerde of onderweg heeft gehoord. De dialogen zijn te zien als medicijnen tegen (...) wat Coornhert zag als de ziekte van zijn tijd: onnadenkendheid en religieuze scherpslijperij. Enerzijds probeert Coornhert obstakels voor een goed en gelukkig persoonlijk leven weg te halen. Hier gaat het vooral om het bestrijden van onbegrip en onwetendheid. Anderzijds probeert Coornhert obstakels voor vreedzaam samenleven op te ruimen. Dat is de reden waarom nogal wat dialogen ingaan op religieuze kwesties als kerkbezoek, de mis en kerkelijke ceremonies; onenigheid over deze onderwerpen vormde immers de belangrijkste oorzaak van de heftige onderdrukking, vervolging en oorlog in de zestiende eeuw. Dit verklaart ook de felheid van veel van de dialogen. Discussies over religieuze denkbeelden en gebruiken waren niet zomaar interessant tijdverdrijf voor bij de borrel. Het ging ergens om: om de waarheid, je zielenheil en de inrichting van de maatschappij. In 45 dialogen probeert Coornhert zo zijn medemens te motiveren tot eerlijkheid naar zichzelf en verdraagzaamheid naar de ander. (shrink)

The problem of salvation of non-Muslims is a crucial element in the discourse of Islamic modernism. It was no less important for such Islamic thinkers of the classical period as Ibn Qayyim al-Jawziyya and Abu Ḥamid al-Ġazali. The attention of the author of the present paper focuses on understanding the problem of salvation in the teaching of Muhammad Rashid Rida, who was one of the key participants in the modernist movement in Islam. Being a representative of “intellectual salafism”, Rashid Rida (...) proposes a solution for the issue of salvation that comes as an alternative for traditionalist views predominating in Sunni Islam. The present paper serves to prove that Rida’s quite peculiar solution is deeply rooted in Islamic tradition. In particular, it relates to viewpoints of al-Jawziyya and al-Ġazali, which deflect from mainstream. Similar to many other Islamic modernists, the main although not the only argument of Rida is based on the Quranic idea of all-embracing Divine grace. In his analysis of Rida’s position, the author notes that the former does not lean towards the liberal variant of Islamic reformism that supposes religious pluralism as one of its basic ideas. Advocating the superiority of Muhammad’s message, the Egyptian thinker adhered to a specific form of soteriological inclusivism that differs from religious pluralism. According to Rida, the main criterion for one’s salvation is whether one was touched upon by undistorted Islamic message or not. Rida was convinced that Gehenna only awaits those non-Muslims who received undistorted Islamic message, clearly understood its Divine source and thenintentionally rejected it. But even they may be redeemed, as God is not obligated to act on his declared threat. (shrink)

Potential conflicts between the roles of physicians and researchers have been described at the theoretical level in the bioethics literature (Czoli, et al., 2011). Physicians and researchers are generally in mutually distinct roles, responsible for patients and participants respectively. With increasing emphasis on integration of research into clinical settings, however, the role divide is sometimes unclear. Consequently, physician–researchers must consider and negotiate salient ethical differences between clinical– and research–based obligations (Miller et al, 1998). This paper explores the subjective experiences and (...) perspectives of 30 physician–researchers working in three Canadian paediatric settings. Drawing on qualitative interviews, it identifies ethical challenges and strategies used by physician–researchers in managing dual roles. It considers whether competing obligations could have both positive and adverse consequences for both physician–researchers and patients. Finally, we discuss how empirical work, which explores the perspectives of those engaged in research and clinical practice, can lead the way to understanding and promoting best practice. (shrink)

A partir de una encuesta por correo electrónico a estudiantes de Ingeniería en el SAI de la UAMA en un contexto de enseñanza remota forzado por la pandemia, se caracteriza la gestión de la docencia, desde la visión de los estudiantes, se realiza un diagnóstico de los aspectos relacionados. Es un estudio transversal con un análisis cualitativo y descriptivo de las respuestas. La gestión docente se ve afectada por factores inherentes al proceso, así como también por factores externos. Los resultados (...) obtenidos muestran que fue impactada fuertemente al realizarse el proceso totalmente vía remota especialmente, la comunicación e interacción alumno-profesor. (shrink)

In this paper, we continue with the study of tense operators on Nelson algebras (Figallo et al. in Studia Logica 109(2):285–312, 2021, Studia Logica 110(1):241–263, 2022). We define the variety of algebras, which we call tense Nelson D-algebras, as a natural extension of tense De Morgan algebras (Figallo and Pelaitay in Logic J IGPL 22(2):255–267, 2014). In particular, we give a discrete duality for these algebras. To do this, we will extend the representation theorems for Nelson algebras given in Sendlewski (...) (Studia Logica 43(3):257–280, 1984) to the tense case. (shrink)

Averroës, 1126-1198; criticism and interpretation; Islamic philosophy; Religion and ploitics.

Рассматриваются актуальные проблемы философской антропологии, проводится анализ парадоксов и противоречий, возникающих при изучении человека, тех кардинальных сдвигов в культуре, которые открыли новые стороны человеческого бытия. Для студентов.

Violence is a natural human state, a natural means of communication between one individual and another and it will remain so as long as society is in the stage of its "animal" evolution, as long as man in the mass remains, as Nietzsche put it, a "superchimpanzee." Violence is natural, and goodness and altruism are artificial; one must make a great effort to be good. To be good is an art. There are no laws that make us love one another. (...) But there are laws according to which we must fear or hate, or try to subjugate others. These are the laws of nature. (shrink)